Michael Klering, from Kentucky, told a nearby supporter he was "terrified to death" when he apparently woke up and saw his room was "secured in smoke" after the cell phone burst into flames.
Mr Klering told WKYT: "The entire room simply secured in smoke, smells terrible. I look over and my telephone is ablaze.
The telephone should be the substitution, so you would have thought it would be protected. It wasn't connected to. It wasn't anything, it was simply staying there."
It comes days after another substitution of the Note 7 supposedly detonated on a plane, prompting a mass clearing of the flight at Louisville Airport.
Toward the end of September Samsung declared a worldwide review of the Note 7, saying the issue had been distinguished and altered the issue and that the organization would give substitution telephones to anybody influenced.
Samsung suspended offers of the new cell phone after no less than 35 cases were accounted for of telephone harm inside two weeks of its discharge.
In light of the most recent episode, Samsung told WKYT: "We need to promise our clients that we consider each report important and we are locked in with Mr. Klering to guarantee we are doing all that we can for him. Client wellbeing remains our most noteworthy need as we are examining the matter."